Fatigue Mechanisms in Skeletal Muscle During Prolonged Isometric Contraction: Metabolic and Electrophysiological Insights
Abstract
Fatigue is a common phenomenon during prolonged isometric contractions, affecting muscle performance and endurance. This paper investigates the underlying mechanisms of muscle fatigue during sustained isometric activity, focusing on metabolic changes, ion homeostasis, and alterations in electrophysiological properties. Through an analysis of muscle metabolites (e.g., ATP, lactate) and electromyographic (EMG) signals, the study examines how factors such as reduced calcium sensitivity, accumulation of inorganic phosphate, and altered motor unit firing contribute to the decline in force production. The findings have implications for developing strategies to mitigate fatigue in clinical and athletic settings, including optimizing training regimens and enhancing recovery protocols.
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